Holmium in PDB 4bdw: The Structure of the Fni-Egf Tandem Domain of Coagulation Factor XII in Complex with Holmium

All present enzymatic activity of The Structure of the Fni-Egf Tandem Domain of Coagulation Factor XII in Complex with Holmium:
3.4.21.38;

The structure of The Structure of the Fni-Egf Tandem Domain of Coagulation Factor XII in Complex with Holmium, PDB code: 4bdw was solved by D.X.Beringer, L.M.J.Kroon-Batenburg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.12 / 2.50
Space group	I 41 2 2
Cell size a, b, c (Å), α, β, γ (°)	96.245, 96.245, 47.331, 90.00, 90.00, 90.00
R / Rfree (%)	21.9 / 23.5

The structure of The Structure of the Fni-Egf Tandem Domain of Coagulation Factor XII in Complex with Holmium also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Holmium atom in the The Structure of the Fni-Egf Tandem Domain of Coagulation Factor XII in Complex with Holmium (pdb code 4bdw). This binding sites where shown within 5.0 Angstroms radius around Holmium atom.
In total 2 binding sites of Holmium where determined in the The Structure of the Fni-Egf Tandem Domain of Coagulation Factor XII in Complex with Holmium, PDB code: 4bdw:
Jump to Holmium binding site number: 1; 2;

Holmium binding site 1 out of 2 in the The Structure of the Fni-Egf Tandem Domain of Coagulation Factor XII in Complex with Holmium


Mono view


Stereo pair view

A full contact list of Holmium with other atoms in the Ho binding site number 1 of The Structure of the Fni-Egf Tandem Domain of Coagulation Factor XII in Complex with Holmium within 5.0Å range: probe atom residue distance (Å) B Occ A:Ho1086 b:78.6 occ:1.00 OXT A:ALA85 2.4 96.2 1.0 C A:ALA85 2.5 96.5 1.0 OD2 A:ASP82 2.5 89.5 1.0 OD1 A:ASP82 2.6 89.0 1.0 O A:ALA85 2.7 94.1 1.0 CG A:ASP82 2.8 87.7 1.0 O A:THR83 2.9 89.3 1.0 N A:ALA85 3.2 97.4 1.0 O A:HOH2014 3.4 70.2 1.0 CA A:ALA85 3.4 99.6 1.0 C A:THR83 3.5 86.0 1.0 HO A:HO1087 3.7 79.2 1.0 N A:THR83 3.7 82.7 1.0 O A:HOH2012 3.8 40.5 1.0 CA A:THR83 4.1 82.5 1.0 C A:ASP82 4.2 81.3 1.0 CB A:ASP82 4.2 85.8 1.0 N A:ALA84 4.4 88.1 1.0 C A:ALA84 4.4 96.1 1.0 CB A:ALA85 4.4 98.8 1.0 O A:GLY73 4.6 77.0 1.0 CA A:ASP82 4.6 80.9 1.0 O A:ASP82 4.8 83.3 1.0 O A:HOH2013 4.8 58.2 0.5 CA A:ALA84 4.8 90.9 1.0

Holmium binding site 2 out of 2 in the The Structure of the Fni-Egf Tandem Domain of Coagulation Factor XII in Complex with Holmium


Mono view


Stereo pair view

A full contact list of Holmium with other atoms in the Ho binding site number 2 of The Structure of the Fni-Egf Tandem Domain of Coagulation Factor XII in Complex with Holmium within 5.0Å range: probe atom residue distance (Å) B Occ A:Ho1087 b:79.2 occ:1.00 O A:HOH2014 2.5 70.2 1.0 O A:HOH2012 2.6 40.5 1.0 O A:HOH2013 2.6 58.2 0.5 O A:HOH2015 2.8 57.1 1.0 O A:ALA85 3.2 94.1 1.0 OXT A:ALA85 3.4 96.2 1.0 HO A:HO1086 3.7 78.6 1.0 C A:ALA85 3.8 96.5 1.0 OD1 A:ASP82 3.9 89.0 1.0 OD2 A:ASP82 4.5 89.5 1.0 CG A:ASP82 4.6 87.7 1.0

D.X.Beringer, L.M.J.Kroon-Batenburg. The Structure of the Fni-Egf-Like Tandem Domain of Coagulation Factor XII Solved Using Siras. Acta Crystallogr.,Sect.F V. 69 94 2013.
ISSN: ESSN 1744-3091
PubMed: 23385745
DOI: 10.1107/S1744309113000286